Manipulation with mitochondria in IVF, in particular, mitochondrial transfer (cytoplasmic donation, pronuclear transfer), is presented as a revolutionary method that allows you to abandon donor eggs and give birth to a healthy genetically native child. However, we at Feskov Human Reproduction Group understand the background of the process and consider it necessary to convey to the future parents the real situation.
What is mitochondrial transfer?
Mitochondrial transfer is the introduction of the cytoplasm of a donor oocyte (containing RNA, DNA and mitochondria - sources of cellular energy) into the egg of the future mother. Manipulation helps to eliminate the energy and metabolic defects of a woman’s own eggs, restores the normal development of the embryo (provided there are no mitochondrial diseases in the expectant mother). That is, the created embryo will receive mitochondrial DNA from the donor, and nuclear (genotype) from the parents. Children born by this method are often called "children from three parents."
Let's learn in more detail about mitochondrial transfer and other types of manipulations with mitochondria are used. First of all, it allows the egg after fertilization to reach the blastocyst stage (the stage of development of the embryo, at which it is able to successfully implant into the uterine cavity). That is, to cover ONLY the energy deficiencies of the egg, no more. It is impossible to exclude chromosomal and genetic pathologies in the fetus using this method!
But this is not all the weak areas of this ART. Getting a blastocyst is not enough: even a quality embryo at this stage does not guarantee pregnancy (remind you that about 80% of success depends on genetics).
Application of the method
In pronuclear transfer, parental genetics is used. Given that the procedure is recommended for couples older than 40 years, there is a risk of developing chromosomal abnormalities (at this age, anomalies reach the chromosomal level). No matter how developed reproductive technologies are, it is still impossible to overcome this natural process.
Indications for the use of the method of pronuclear transfer
The main indication is multiple failed IVF attempts, due to the following reasons:
- Reduced frequency or lack of fertilization;
- Abnormal embryo fragmentation;
- Decreased dynamics of embryo development;
- Failure of implantation of embryos.
Cytoplasmic donation can also be recommended for women of older reproductive age (37+) for egg revitalization before a planned pregnancy.
What approach and guarantees does the Feskov Human Reproduction Group offer?
Mitochondrial treatment services are experimental, therefore, if the couple did not manage to achieve pregnancy from the first attempt, we carry out the program until the long-awaited pregnancy is achieved.
Stages of the mitochondrial transfer program
We start the program in the conditions of our clinic, with the preparation according to our program of a woman for getting eggs, with the careful selection of sperm according to our technologies. Embryos are created by our embryologists, who have adopted the experience of domestic and foreign colleagues (Japan, China, Sweden).
If we don’t get blastocysts (and according to direct and indirect indicators of embryo development, the egg has its negative contribution) - only then can we use mitochondrial treatment.
Watch the video about mitochondrial transfer
Advantages and disadvantages of mitochondrial transfer
Advantages of mitochondrial treatment:
- High theoretical effectiveness;
- Great potential results.
However, all this has only potential, with unproven real effectiveness.
Disadvantages of mitochondrial treatment:
- High price of procedures;
- High traumatic effects during manipulation with mitochondria;
- There is no guarantee of the effect on the genetics of the embryos (even if the mitochondrial transfer is successful, it is impossible to guarantee that the embryo will be healthy).
Guaranteed Feskov HRG programs contain service packages with additional mitochondrial transfer attempts at no extra charge. In case of failure, the clinic provides them for free.
In Deluxe packages, an unlimited number of repeated cytoplasmic donation procedures is available; in VIP plus packages, a limited number of attempts are available.
Learn more about the indications, contraindications and prospects of the technique from our specialists. We will help you choose the most effective approach in each individual case.
You can get detailed information about the service from the manager by filling out the form on the website.
Or in another way convenient for you